Duplicate gene enrichment and expression pattern diversification in multicellularity

Duplicate gene enrichment and expression pattern diversification in multicellularity

The enrichment of duplicate genes, and therefore paralogs (proteins coded by duplicate genes), in multicellular versus unicellular organisms enhances genomic functional innovation. This study quantitatively examined relationships among paralog enrichment, expression pattern diversification and multicellularity, aiming to better understand genomic basis of multicellularity. Paralog abundance in ...

Gene Expression and Methylation Pattern in HRK Apoptotic Gene in Myelodysplastic Syndrome

Myelodysplastic syndromes (MDSs) are a clonal bone marrow (BM) disease characterized by ineffective hematopoiesis, dysplastic maturation and progression to acute myeloid leukemia (AML). Methylation silencing of HRK has been found in several human malignancies. In this study, we explored the association of HRK methylation status with its expression, clinical parameters and MDS subtypes in MDS pa...

Gene expression pattern in different tissues of mudskipper (Boleophthalmus dussumieri)

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Divergence in the spatial pattern of gene expression between human duplicate genes.

Microarray gene expression data provide a wealth of information for elucidating the mode and tempo of molecular evolution. In the present study,we analyze the spatial expression pattern of human duplicate gene pairs by using oligonucleotide microarray data,and study the relationship between coding sequence divergence and expression divergence. First,we find a strong positive correlation between...

Different genome amplification mechanisms and duplicate gene expression in Liliaceae.